The main focus of my research interests can be summarized into these five specific
- Medical-biological applications of both cyanoxime ligands and their bivalent Pd and
- New light-insensitive Ag(I) cyanoxime compounds and their antimicrobial properties.
- New organoantimony(V) compounds as non-antibiotic antimicrobials.
- Self-assembled cytotoxic Pt(II) coordination polymers that emit light in the NIR region.
- X-ray crystallography of small molecules.
Today 39 different cyanoximes are obtained, characterized and available for further
studies. Presence of the –CN group by 10 – 10000 times increases acidity of compounds
which makes them better ligands due to easy formation of planar, conjugated yellow
colored anions. They readily form numerous coordination compounds with p-, d- metals
and lanthanides as oppose to other known monoximes such as aldoximes and ketoximes.
Many cyanoximes and their metal derivatives have shown significant biological activity
ranging from antimicrobial and cytotic, to growth regulation in plants and organophosphorous
pesticides detoxifying agents (antidots).
This side of biological properties of these compounds is reflected in many patents,
presentations and publications. One of research projects in my group is dedicated
to synthesis, characterization and in vitro biological studies of antimicrobial activity
(Ag complexes) and cytotoxicity (Pd, Pt; organotin(IV)) of a large group of previously
unknown metallocyanoximates. This work is carried out in collaboration with Prof.
Paul Durham from MSU Biology Department.
Another project is dealing with preparation of coordination polymers with metal ions
such as Tl(I) or Pt(II) in close special proximity to each other, often almost as
close as distance in these metallic elements. Third research project is dedicated
to investigations of properties of a group of visible light insensitive Ag(I) complexes
that are able to develop sharp and contrast image after exposure to high energy photons
such as UV- and X-ray radiation.